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Authors:

Ihab Abumuhor, BS, MT (ASCP)

Ellen Hope Kearns, MS, SH(ASCP)H

Division of Health Sciences, School of Health, California State University Dominguez Hills, Carson, CA

Thrombotic Thrombocytopenic Purpura

Etiology


The disease may be precipitated by the use of estrogen or pregnancy. Pregnancy-associated TTP and the postpartum state accounts for 10-25% of TTP patients and usually presents before 24 weeks of gestation.

TTP is frequently preceded by a viral or bacterial infection. It is also associated with the human immunodeficiency virus (HIV).

There are also a vast array of causes which include cancer, collagen, and vascular disorders, as well as drug sensitivities. Non-cancer chemotherapeutic and other drugs suspect in causing TTP include: immunosuppressive agents (e.g., cyclosporine A), ticlopidine, penicillin, and rifampin. Toxins associated with TTP are E. coli 0157:H7, and spider and bee venom. Cancer chemotherapeutic agents associated with TTP include: tamoxifen, bleomycin, and mitomycin.


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Last Update: September 11 2012