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Ihab Abumuhor, BS, MT (ASCP)

Ellen Hope Kearns, MS, SH(ASCP)H

Division of Health Sciences, School of Health, California State University Dominguez Hills, Carson, CA

Thrombotic Thrombocytopenic Purpura

Morbidity and Mortality

In the U.S.A, over 75 years ago the occurrence rate of this uncommon disorder was one/one million patients; however, the incidence may be increasing. One report has a case rate of 1/6,000 hospital admissions. The mortality rate associated with TTP was 100% until 1980s when management therapy improved. Presently, the mortality rate is approximately 95% for untreated cases. The survival rate is 80-90% with early diagnosis and treatment with plasma infusion and plasma exchange. One-third of the patients who survive the initial episode experience relapse within 10 years.

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Last Update: September 11 2012